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KMID : 0616620090150020013
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Journal of Soonchunhyang Medical College
2009 Volume.15 No. 2 p.13 ~ p.18
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Rapid Diagnosis of Malaria: Clinical Manifestations and Comparison of
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Kim Byung-Chul
Park Ro-Jin
Kim Tae-Hyong
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Abstract
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Background:Malarial infestation intermediated by Anopheles mosquito is one of the most prevalent parasitic diseases over the world and many people are infected by malarial plasmodium each year. The rapid diagnosis is needed to properly treat the malaria because plasmodium falciparum has a high mortality rate. Currently, we usually use a microscopic examination of blood smears for diagnosis of malaria and it has a high sensitivity and specificity, However, the result might depend on physician in change and this method needs much time for diagnosis of malaria.
Methods:We evaluated 206 patients who were suspicious of malaria. We perforemed a microscopic examination of blood smears and antigen detection test. We investigated clinical symtoms such as fever pattern, thrombocytopenia, anemia and diagnosised as malaria who was positive in blood smears. After this we tried to follow up the patients,
Results:As a result of a microscopic examination of blood smears and antigen detection test for 206 patients who were suspicious of malaria, 15 was diagnosed with malaria infestation and all of them showed a positive response to malarial antigen test . There were six patients who showed a positive reaction to antigen test, but negative results in blood smears. Malarial patients showed anemia, leukopenia or thrombocytopenia and revealed the symtom of splenomegaly, headache and abdominal pain.
Conclusions:Malarial antigen test has a good relationship with a microscopic examination of blood smears and a high sensitivity and specificity. Because the result could be false positive or false negative, it might be helpful to perform antibody test together.
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KEYWORD
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Malaria, Microscopic examination of blood smears, Antigen detection test
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